This is a good read by VG247 where they have conducted an interview with the main brain behind Obsidian who has revealed the way they approach in-game choices and to the degree in how nuanced they should be. Refreshing and informative and really makes me want to try New Vegas which I have been itching to do!
The anatomy of a good in-game choice, according to Obsidian | VG247
After reading, it's safe to say that having them do Fallout 5 would be great to see.