I prefer Ford to the other two. Ford to me, seems to have more refinement than the other two, from experience from at least one of the cars from each manufacture.
Chrysler:
I've never been a fan of Chrysler due to their quality and the fact they don't handle well (rented a 300 in Puerto Rico)....excluding the Dodge Viper, but maybe a 300C might change my mind.
General Motors:
With GM, I'm impressed with interior quality in the Escalade, but I need to be in a lot more cars to be sure (been in Escalade and DTS). What I don't like is their powertrains in some of their cars. The Escalade has problems deciding to shift gears with two overdrive gears (probably because it's a rental), but there is no center console. I'm not a fanboy of GM, but I don't want them to die. There's the CTS-V, Corvette (one of my favorite sports cars), and Camaro.
Ford:
I'm impressed with how they've changed. Quality has changed, but then again everyone has. Powertrains are getting a lot better with plenty of power and refinement (like GM), although I wish they would have more powerful engine in the 3rd generation Navigator. They've always seem to meet my family's needs and right now, they are doing better financially then the other two, and haven't taken any bailout money yet. I forever will be a Ford fanboy, and no day in my life I'll change to the other two. Plus, they made the first premium full-size luxury SUV from America, and also made the first American premium full-size luxury SUV with IRS!
Don't forget the Ford GT!